Will smoking cause a person to metabolize WLF1 faster? if it does, will that affect the bioavailability of the herbs?

Preliminary laboratory research indicates that some ingredients in WLF1 may affect the action of some of the P450 isozymes—CYP1A2, CYP2E1, and CYP3A4—that play an important role in drug metabolism. As a result, the rate of drug metabolism can be faster (or slower) when the drug is taken with WLF1. For this reason, we encourage customers to talk to their medical doctor before adding this (or any dietary supplement) to their health routine.


Here is an overview of potential herb-drug interactions that may occur when WLF1 is taken together with certain medications:1

Green Coffee Extract. The product contains a green coffee bean extract. In general terms, coffee (separate and apart from caffeine) has been reported to induce the drug-metabolizing isozyme CYP1A2. This action could increase the rate of metabolism for acetaminophen (Tylenol) and other drugs metabolized by this isozyme.
Rhodiola. The product contains Rhodiola rosea root extract. Preliminary research in animals (rabbits) indicates rhodiola slows down the metabolism of losartan, a blood pressure drug, when taken at the same time. This may increase the drug’s effect. This action is attributed, in part, to altering the effect of one or more drug-metabolizing enzymes in the cytochrome p450 family.2 More research is needed to confirm a similar effect in humans.
Black Pepper. The product contains black pepper fruit extract standardized to piperine. Preliminary cell culture and animal studies (rats) suggest that piperine may affect some drug-metabolizing enzymes in the cytochrome p450 family. Piperine is reported to inhibit CYP2E1, which metabolizes theophylline (Theo-Dur), acetaminophen (Tylenol) and other drugs. It also inhibits CYP3A4, which metabolizes lovastatin (Liptor), finasteride (Proscar), omeprazole (Prilosec) and many other drugs. This suggests it may slow down the metabolism of these drugs; however more research is needed to confirm similar effects in humans.

References
1. Batz F, Young VSL, Gurley B, eds. Herb-Drug Interaction Handbook, 3rd ed. Castleton, NY: Church Street Books; 2005.
2. Spanakis M, Vizirianakis IS, Batzias G, Niopas I. Pharmacokinetic interaction between losartan and Rhodiola rosea in rabbits. Pharmacology. 2013;91(1-2):112-116. PMID: 23327826.

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